The 6th PFMR Biomedical Research Symposium-CALL FOR ABSTRACTS

CALL FOR ABSTRACTS

6th PFMR Biomedical Research Symposium

April 9, 2016

Shucri Ibrahim Dabdoub Faculty of Business Administration

Furno Hall, Bethlehem University

Dear Colleagues,

The Palestinian Forum for Medical Research (PFMR) in conjunction with the Department of Life Sciences, Faculty of Science, and Bethlehem University is organizing “The Sixth Biomedical Research Symposium”. The symposium’s goal is to present research conducted by Palestinian students and researchers as well as bringing together young and hopeful scientific minds.

 

We cordially invite you to present your work either by giving a presentation or presenting a poster. For those wishing to participate, please submit your abstract by March 1st 2016. Researchers will be informed of the acceptance of their abstracts no later than March 20th 2016. Students have the option to submit abstracts for consideration for oral or poster presentation.

The purpose of the abstract is:

  1. To enable the Scientific Committee to make an informed decision on the suitability of the proposed presentation for the symposium program.
  2. To provide participants attending the symposium with the summary of the work being presented.

Abstracts are invited from all areas of biomedical research including, but not limited to:

 

  • Public Health                                                     ● Anatomy and Physiology
  • Microbiology                                                      ● Pathology and Histopathology
  • Genetics                                                               ● Haematology
  • Cancer                                                                  ● Pharmacology and Toxicology
  • Parasitology                                                       ● Aging
  • Virology                                                               ● Clinical Research
  • Immunology                                                       ● Neuroscience
  • Genomics and Proteomics                              ● Pharmaceutics
  • Bioinformatics                                                   ● Health Informatics
  • Biomedical ethics, Governance Challenges, and Regulations
  • Epidemiology

Please send your abstract as an attached Microsoft word document to the following e-mails: biomed@bethlehem.edu; pfmr.pfmr@gmail.com

Guidelines for Author’s Preparation of Abstracts

Title: The title should be in bold, upper case letters with no full stop at the end

Authors: Names of authors should be in Times New Roman, size 12 fonts, as first name and surname with no full stop. Underline the name of the corresponding author. Author names should be separated by a comma. Where authors are from a number of different institutions, the appropriate institution number from the affiliation list should be given as a superscript number immediately after each author’s name.

 

Affiliations: Affiliations should include department, institute, town and country. Where there are multiple affiliations, each should be listed as a separate paragraph. Each institute should appear in the order used against the author names and show the appropriate superscript number.

 

Main text:

  • Authors may submit a regular or a structured abstract.
  • Should not be more than 400 words.
    • Please use Times New Roman, size 12 fonts and single line spacing.
    • Greek and other special characters may be included. If you are unable to reproduce a particular special character, please type out the name of the symbol in full.
    • Web links (URLs) should be provided in full, including both the title of the site and the URL, in the following format: Mouse Tumor Biology Database [http://tumor.informatics.jax.org/cancer_links.html], include also the accessed date
    • Abbreviations should be used as sparingly as possible.

 

Structured abstracts In structured abstracts, paragraph headings should be typed in bold with no colon at the end. Each heading should be in a separate paragraph:

Background

Followed by regular text, on a new line and in the same format as indicated for the main text.

Materials and Methods

Results

Conclusions


The following represents an example of how a regular abstract should be presented:

 

Toward building up an algorithm to predict the outcome of nonsense mutations

1Fouad Zahdeh and 1Moien Kanaan

1 Hereditary Research Laboratory, Faculty of Science, Bethlehem University

fouadb@bethlehem.edu

Background

Nonsense-mediated decay (NMD) is a euka­ryotic mRNA surveillance mechanism that targets for degradation transcripts that harbor a premature termination codon (PTC). UPF1, the activator of NMD, can also target normal isoforms; thus, NMD is also a regulator of gene expression. Among the reported features that are known to trigger NMD are exon junction complex (EJC) downstream the termination codon, long 3’UTR, short coding sequence (CDS), upstream open reading frame (uORF), and the presence of 3’UTR G-rich sequence. Yet, there are many examples of NMD-targets that lack any of these features. The purpose of this study is to test known NMD-triggering features and to identify others to build up a prediction model of the outcome of nonsense mutations.

Methods

We developed a robust measure of mRNA stability from RNA-seq of normal and UPF1-depleted cells. Reads were mapped and assembled using Tophat and Cufflinks. We measured the stability change of 6080 human transcripts, and we developed a test to find transcripts that are significantly stabilized upon inhibiting NMD (i.e. NMD-targets). The features of NMD-targets were compared to transcripts that show no change in stability (non-targets) using nonparametric effect-size, relative entropy, and hypergeometric random variable.

Results

In contrast to the prevailing theory, 3’UTR of NMD-targets weren’t longer than non-targets, and not enriched in EJC. However, we found that 3’UTR and CDS nucleotides content were significantly correlated with stability change. G-rich sequences and C-rich sequences were significantly enriched in the 3’UTR and CDS of NMD-targets. Moreover, 3’UTR of PTC mutations that result in haplo-insufficiency harbor more runs of G than their wildtype. We identified long CDS as NMD-triggering feature in NMD-targets that have low G-content, and we also identified short 3’UTR as an NMD-escaping feature in transcripts with high G-content.

Conclusion

This study is the first step in developing an algorithm to predict whether a stop mutation would result in truncation protein (non-target) or haplo-insufficiency (NMD-target).

 

 

 

 

Poster Information, Size and Layout

Each author will share a poster board with one other author, and each will have a useable area measuring 86.cm wide and 100 cm high. This is a portrait/vertical format. Poster materials may not extend outside the assigned half-board.

Designing Effective Posters

Effective poster design requires careful thought and advance preparation. The following suggestions will help in preparing effective posters.

  • Identify 2-3 principal messages you have to convey. Choose a title that captures your main point.
  • Prepare a heading at the top of your poster indicating the abstract title, authors, and affiliations. Lettering should be at least 2.0 cm high.
  • Summarize current research in graphic form whenever possible; use charts, tables, graphs, pictures, etc. and minimize the amount of text.
  • Arrange materials in columns and use ‘white space’ to help direct readers logically through your poster.
  • Prepare your poster on laminated poster paper, fabric, or cardboard, allowing for space to mount it on the poster board with push pins.
  • Posters should be self-explanatory but not comprehensive. You will supplement and elaborate during your conversations with others.

Tips for Illustrations

  • Your presentation must be readable from distances of at least (90 cm). Keep visuals simple and clear.
  • Provide information in smaller type below the heading. Details of methodology should be brief and should be placed at the end of the legend.
  • Simple use of color can add emphasis.
  • Do not write or paint directly on the poster boards.

 

Categories Uncategorized | Tags: | Posted on January 28, 2016

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